Our research focuses on the syntheses of novel and small molecules that can act as tyrosinase inhibitors, HDAC inhibitors, PPAR a/g dual agonists, S6K inhibitors, tyrosine kinase inhibitors, Sirt inhibitors or Sirt activators and the discovery of their structure-activity relationships on the new templates essential for potent biological activity.

Selected Publications

1. Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2- (2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384). Biochim. Biophys. Acta (2012) 1820, 542-549.
2. Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4-dihydroxybenzylidene) pyrrolidine-2,5-dione (3-DBP). Biochim. Biophys. Acta (2012) 1820, 962-969.
3. Design and synthesis of 5-(substituted benzylidene)thiazolidine -2,4-dione derivatives as novel tyrosinase inhibitors. Eur. J. Med. Chem. (2012) 49, 245-252.
4. Design, synthesis, and evaluation of (E)-N-substituted benzylidene- aniline derivatives as tyrosinase inhibitors. Eur. J. Med. Chem. (2012) 57, 383-390.
5. Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide/protein kinase G signaling pathway in murine skin. J. Dermatol. Sci. (2012) 68, 164-171.