Students will learn various analytical methods such as isolation/purification, structural elucidation, analysis of biosynthetic pathways, and activity evaluation of compounds derived from natural materials. Through this, they will evaluate the potential for drug development of newly discovered compounds and learn how to apply them in various pharmaceutical areas.

Selected Publications

1. Lee, Seoung Rak; Seyedsayamdost, R. Mohammad. Induction of diverse cryptic fungal metabolites by steroids and channel blockers. Angew. Chem. Int. Ed. 2022. 61, e202204519.

2. Lee, Seoung Rak; Schalk, Felix; Schwitalla, Jan W.; Guo, Huijuan; Yu, Jae Sik; Song, Moon-yong; Jung, Won Hee; de Beer, Z. Wilhem; Beemelmanns, Christine; Kim, Ki Hyun. GNPS-guided discovery of madurastatins A1, A2, E1, F, and G1, siderophores from the termite-associated Actinomadura sp. RB99. Chem. Eur. J. 2022, 28, e202200612.

3. Lee, Seulah; Yu, Jae Sik; Lee, Seoung Rak; Kim, Ki Hyun. Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis. Nat. Prod. Rep. 2022, 39, 512-559

4. Lee, Seoung Rak; Guo, Huijuan; Yu, Jae Sik; Park, Minji; Dahse, Hans-Martin; Jung, Won Hee; Beemelmanns Christine; Kim, Ki Hyun. Revised structural assignment of azalomycins based on genomic and chemical analysis. Org. Chem. Front. 2021, 8, 4791.

5. Lee, Seoung Rak; Seok, Soonja; Ryoo, Rhim; Choi, Sang Un; Kim, Ki Hyun. Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom Podostroma cornu-damae. J. Nat. Prod. 2019, 82, 122-128.