The Laboratory of Molecular Neurobiology employs in vitro and in vivo experimental models of aging and age-related neurodegenerative disorders in order to understand the molecular mechanisms of age-related neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). We are currently using neural progenior cells that can be differentiated to neuron or astrocytes, and primary neurons derived from the embryonic brain. Obtained data from in vitro studies are integrated with data from in vivo neurodegenerative diseases models of AD and PD. Ultimately, our research focus on developing the preventative and therapeutical ways of age-related neurological disorders through regulating adult hippocampal neurogenesis.

Selected Publications

1. Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation. Kim HS, Son TG, Park HR, Lee Y, Jung Y, Ishigami A, Lee J. Neurobiol Aging. 2013 Apr;34(4):1177-83
2. Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. Park HR, Kong KH, Yu BP, Mattson MP, Lee J. J Biol Chem. 2012 Dec 14;287(51):42588-600.
3. Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee J. Br J Pharmacol. 2013 Jan;168(2):421-31.
4. High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. Toxicology. 2012 Jun 14;296(1-3):73-82.
5. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo DG, Chung HY, Ha NC, Mattson MP, Lee J. Neurobiol Dis. 2011 Nov;44(2):223-30.