Our lab is interested in the molecular and biochemical mechanisms underlying aging process, especially focusing on molecular inflammation and vascular aging, and development of anti-aging drugs for life-prolonging intervention.

Selected Publications

1. Moon, K.M., Lee, B., Kim, D.H., Chung, H.Y.: FoxO6 inhibits melanogenesis partly by elevating intercellular antioxidant capacity. Redox Biol. in press (2020)

2. Lee, A.K., Kim, D.H., Bang, E., Choi, Y.J., Chung, H.Y.: β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling. Aging Dis. 11(4):777-790 (2020)

3. Kim, D.H., Kim, B.M., Chung, K.W., Choi, Y.J., Yu, B.P., Chung, H.Y.: Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation. Liver Int. in press (2020)

4. Kim, D.H., Bang, E., Jung, H.J., Noh, S.G., Yu, B.P., Choi, Y.J., Chung, H.Y.: Anti-aging Effects of Calorie Restriction (CR) and CR Mimetics based on the Senoinflammation Concept. Nutrients. 12(2):422 (2020)

5. Lee, S., Lee, Y., Ha, S., Chung, H.Y., Kim, H., Hur, J.S., Lee, J., Lee, S., et al.,: Anti-inflammatory effects of usnic acid in an MPTP-induced mouse model of Parkinson’s disease. Brain Res. in press (2020)

6. Hayakawa, K., Tang, N., Nagato, E., Toriba, A., Lin, J.M., Zhao, L., Zhou, Z., Qing, W., Yang, X., Mishukov, V., Neroda, A., Chung, H.Y.: Long-Term Trends in Urban Atmospheric Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons: China, Russia, and Korea from 1999 to 2014. Int J Environ Res Public Health. 17(2):431 (2020)

7. Chung, K.W., Chung, H.Y.: The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention. Nutrients. 11(12):2923 (2019)

8. Kim, D.H., Ha, S., Choi, Y. J., Dong, H. H, Yu B. P, Chung, H.Y.: Altered FoxO1 and PPARγ interaction in age-related ER stress-induced hepatic steatosis. Aging 11(12):4125-4144 (2019)

9. Kim, D.H., Lee, B., Lee.,J., Kim, M.E., Lee, J.S., Chung, J.H.,Yu, B.P., Dong, H.H.,:  FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice. Redox Biol. 24:101184 (2019)

10. Jung, H.J., Noh, S.G., Park, Y., Kang, D., Chun, P., Chung, H.Y., Moon, H.R.: In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives. Comput Struct Biotechnol J. 17:1255-1264 (2019)

11. Chung, H.Y., Kim, D.H., Lee, E.K., Chung, K.W., Chung, S.W., Lee, B., Seo, A.Y., Chung, J.H., Jung, Y.S., Im, E., Lee, J.W., Kim, N.D., Choi, Y.J., Im, D.S., Yu, B.P.: Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept. Aging and Dis.10(2):267-382 (2019)

12. Kim, D.H., Park, M.H., Ha, S., Bang, E., Lee, Y.J., Lee, A.K., Lee, J., Yu, B.P., Chung, H.Y.: Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction. Aging (Albany NY) 11(4):1283-1304 (2019)

13. Kim, D.H., Park, J.W., Jeong, H.O., Lee, B., Chung, K.W., Lee, Y.J., Jung, H.J., Hyung, M.K., Lee, A.K., Kim, B.M., Lee, J., Yu, B.P., Chung, H.Y.: Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging. Aging and Dis. 10(6):1174-1186 (2019)

14. Bang, E., Lee, E.K., Noh, S.G., Jung, H.J., Moon, K.M., Park, M.H., Park, Y.J., Hyun, M.K., Lee, A.K., Kim, S.J., Yang, J., Park, Y., Chun, P., Moon, H.R., Chung, H.Y.: In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT). Exp Dermatol. 28(6):734-737 (2019)

15. Chung, K.W., Lee, E.K., Lee, M.K., Oh, G.T., Yu, B.P., Chung, H.Y.: Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. J AM SOC NEPHROL, 29(4):1223-1237 (2018)

16. Bang, E., Noh, S.G., Ha, S., Jung, H.J., Kim, D.H., Lee, A.K., Hyun, M.K., Kang, D., Lee, S., Park, C., Moon, H.R., Chung, H.Y.: Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico. Molecules. 23(12):3307 (2018)

17. Kim, M.J., Park, C.H., Kim, D.H., Park, M.H., Park, K.C., Hyun, M.K., Lee, A.K., Moon, H.R., Chung, H.Y.: Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats. Molecules, 23(8):2057 (2018)

18. Kim, M.J., An, H.J., Kim, D.H., Lee, B., Lee, H.J., Ullah, S., Kim, S.J., Jeong, H.O., Moon, K.M., Lee, E.K., Yang, J., Akter, J., Chun, P., Moon, H.R., Chung, H.Y.: Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. Bioorg Med Chem Lett, 28(4):684-688 (2018)

19. Jung, H.J., Lee, A.K., Park, Y.J., Lee, S., Kang, D., Jung, Y.S., Chung, H.Y., Moon, H.R.: (2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells. Molecules. 23(6):1415 (2018)

20. Lee, E.K., Chung, K.W., Kim, Y.R., Ha, S., Kim, S.D., Kim, D.H., Jung, K.J., Lee, B., Im, E., Yu, B.P., Chung, H.Y.: Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney. Aging Cell, 16(5):1026-1034 (2017)

21. Chung, K.W., Kim, K.M., Choi, Y.J., An, H.J., Lee, B., Kim, D.H., Lee, E.K., Im, E., Lee, J., Im, D.S., Yu, B.P., Chung, H.Y.: The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis. Autophagy, 13(7), 1113-1129 (2017)

22. Son, J.C., Jeong, H.O., Park, D., No, S.G., Lee, E.K., Lee, J., Chung, H.Y.: miR-10a and miR-204 as a Potential Prognostic Indicator in Low-Grade Gliomas. Cancer Inform, 16, 1-6 (2017)

23. Kim, D.H., Kim, S.M., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., An, H.J., Kim, K.M,. Yu, B.P., Chung, H.Y.: Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. J Nutr Biochem, 45,104-114 (2017)

24. Kim, Y.R., Lee, E.K., Kim, D.H., Kim, K.M., Lee, B., An, H.J., Park, J.W., Moon, K.M., Park, M.H., Chung, K.W., Park, J.Y., Kim, S.J., Yun, H.Y., Son, S., Chun, P., Moon, H.R., Chung, H.Y.: PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol, 92,87-95 (2017)

25. Park, J.W., Ha, Y.M., Kim, D.H., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., Kim, K.M., Park, Y.J., Kim, D.H., Yun, H.Y., Chun, P., Moon, H.R., Chung, H.Y.: 4-(6,7-Dihydro-5H-indeno[5,6-d] thiazol-2-yl)benzene-1,3-diol prevents UV-induced melanogenesis and wrinkle formation in HRM-2 hairless mice. J Dermatol Sci, 84(2),213-216 (2016)

26. Kim, D.H., Lee, B., Kim, M.J., Park, M.H., An, H.J., Lee, E.K., Chung, K.W., Park, J.W., Yu, B.P., Choi, J.S., Chung, H.Y.: Molecular Mechanism of Betaine on Hepatic Lipid Metabolism: Inhibition of Forkhead Box O1 (FoxO1) Binding to Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). J Agric Food Chem, 64(36), 6819-6825 (2016)

27. Kim, C. H., Lee E. K., Choi Y. J., An H. J., Chung H. O., Park D.E., Ghim B. C., Yu B. P., Back J., Chung H. Y.:Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation. Aging Cell, 15(6), 1074-1081 (2016)

28. Park, M.H., Kim, D.H., Kim, M.J., Lee, E.K., An, H.J., Jeong, J.W., Kim, H.R., Kim, S.J., Yu, B.P., Moon, H.R., Chung, H.Y.: Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci,71(3),300-309 (2016)

29. Moon, K.M., Jeong, J.W., Lee, B.G., Kim, D.H., Kim, H.R., Woo, Y.W., Lee, E.K., An, H.J., Kim, M.J., Choi, Y.J., Son, S.J., Chun, P.S., Moon, H.R., Chung, H.Y.: Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signaling. Exp Dermatol, 25(8),652-654 (2016)

30. Chung, K.W., Lee, E.K., Kim, D.H., An, H.J., Kim, N.D., Im, D.S., Lee, J.W., Yu, B.P., Chung H.Y.: Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/1L-1 for steatohepatitis. Aging Cell, 14(4), 524-533 (2015)

31. Chung, K.W., Choi, Y.J., Park, M.H., Jang, E. J., Kim, D.H., Park, B.H., Yu, B.P., Chung, H.Y.: Molecular Insights into SIRT1 Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation. J Gerontol A Biol Sci Med Sci, 70(8), 959-968 (2015)