The research goal of our laboratory is the determination of molecular regulation mechanisms for innate immunity, such as how host can recognize pathogenic microbes and what kinds of molecules modulate host immune systems. For this research, we are using two model systems. One is the gut symbiont-host system, which aims that how symbiont bacteria regulate host innate immunity. The other is that human complement system, which aims to address how human complement system can defense host from pathogenic bacteria invasion.

Selected Publications

1. Specific serum Ig recognizing staphylococcal wall teichoic acid induces complement-mediated opsonophagocytosis against Staphylococcus aureus. Journal of Immunology, 189, 4951-4959 (2012)
2. Novel bacterial lipoprotein structures conserved in low-GC content Gram-positive bacteria are recognized by Toll-like receptor 2. J. Biol. Chem. 287, 13170-13181(2012)
3. 93-kDa Twin-domain Serine Protease Inhibitor (Serpin) Has a Regulatory Function on the Beetle Toll Proteolytic Signaling Cascade J. Biol. Chem. 286, 35087-35095 (2011)
4. Diversity of Innate Immune Recognition Mechanism for Bacterial Polymeric meso-Diaminopimelic Acid-Type Peptidoglycan in Insects, J. Biol. Chem. 285, 32937-32945 (2010)
5. Human serum mannose-binding lectin senses wall teichoic acid glycopolymer of Staphylococcus Aureus, which is restricted in infancy J. Biol. Chem. 285, 27167-27175 (2010)