학력 Education

2001/03 - 2005/02   B.S. , College of Pharmacy, Seoul National University (SNU)
2005/03 - 2011/02   Ph.D. , College of Pharmacy, Seoul National University. Research Advisor: Professor Young-Ger Suh


경력 Experience

2011/03 - 2012/12   Senior Researcher, SNU Research Institute of Pharmaceutical Sciences
2013/01 - 2014/08   Research Associate, The Scripps Research Institute (TSRI). Research Advisor: Professor Peter G. Schultz
2014/09 - 2018/08   Assistant Professor, College of Pharmacy, Pusan National University

2018/09 - 2023/08    Associate Professor, College of Pharmacy, Pusan National University

2023/09 - present      Professor, College of Pharmacy, Pusan National University

연구업적 Achievements

32. Stereoselective Synthesis of 1,4,5-Tri-cis-guaiane Sesquiterpene: First Total Synthesis of (-)-Dendroside C Aglycon, Sim, J.; Park, H.; Lim, J.; Yoon, I.; Lim, C.; An, H.; Yun, H.; Choi, H. J.; Suh, Y.-G. Org. Lett. 2018, 20, 586-589.

31. Total Synthesis of (+)-Brasilenyne via Concise Construction of Oxonane Framework Containing 1,3-cis,cis-Diene, Lim, C.; Ahn, J.; Sim, J.; Yun, H.; Hur, J.; An, H.; Jang, J.; Lee, S.; Suh, Y.-G. Chem. Commun. 2018, 54, 467-470.

30. Asymmetric Total Synthesis of (+)-Intricenyne via an Endocyclization Route to Oxocane Skeleton, Ahn, J.; Lim, C.; Yun, H.; Kim, H. S.; Kwon, S.; Lee, J.; Lee, S.; An, H.; Park, H.-g.; Suh, Y.-G. Org. Lett. 2017, 19, 6642-6645.

29. Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway, Lee, S.-M.; Park, H. Y.; Suh, Y.-S.; Yoon, E. H.; Kim, J.; Jang, W. H.; Lee, W.-S.; Park, S.-G.; Choi, I.-W.; Choi, I.; Kang, S.-W.; Yun, H.; Teshima, T.; Kwon, B.; Seo, S.-K. Proc. Natl. Acad. Sci. U S A. 2017, 114, E5881-E5890.

28. Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis, Jo, J.; Kim, S.-H.; Han, Y. T.; Kwak, J.-H.; Yun, H.* Molecules 2017, 22, 1069.

27. Concise and Efficient Synthesis of 3,7-Dioxo-5β-cholanic Acid via C3,C7-Selective Ketal Protection, Han, Y. T.; Yun, H.* Org. Prep. Proced. Int. 2017, 49, 163-168.

26. Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis, Paek, S.-M.; Jeong, M.; Jo, J.; Heo, Y. M.; Han, Y. T.; Yun, H.* Molecules 2016, 21, 951.

25. Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer, Cao, Y; Rodgers, D. T.; Du, J.; Ahmad, I.; Hampton, E. N.; Ma, J. S. Y.; Mazagova, M.; Choi, S.-h.; Yun, H. Y.; Xiao, H.; Yang, P.; Luo, X.; Lim, R. K. V.; Pugh, H. M.; Wang, F.; Kazane, S. A.; Wright, T. M.; Kim, C. H.; Schultz, P. G.; Young, T. S. Angew. Chem. Int. Ed. 2016, 55, 7520-7524.

24. Divergent synthetic route to new cyclopenta[c]pyran iridoids: syntheses of jatamanin A, F, G and J, gastrolactone and nepetalactone, Sim, J.; Yoon, I.; Yun, H.; An, H.; Suh, Y.-G. Org. Biomol. Chem. 2016, 14, 1244-1251.

23. Versatile strategy for controlling the specificity and activity of engineered T cells, Ma, J. S. Y.; Kim, J. Y.; Kazane S. A.; Choi, S.-h.; Yun, H. Y.; Kim, M. S.; Rodgers, D. T.; Pugh, H. M.; Singer O.; Sun, S. B.; Fonslow, B. R.; Kochenderfer, J. N.; Wright, T. M.; Schultz, P. G.; Young, T. S.; Kim, C. H.; Cao, Y. Proc. Natl. Acad. Sci. U S A. 2016, 113, E450-E458.

22. A Practical and Eco-friendly Synthesis of Oxo-bile Acids, Han, Y. T.; Yun, H.* Org. Prep. Proced. Int. 2016, 48, 55-61.

21. A small molecule inhibits deregulated NRF2 transcriptional activity in cancer, Bollong, M. J.; Yun, H.; Sherwood, L.; Woods, A. K.; Lairson, L. L.; Schultz, P. G. ACS Chemical Biology 2015, 10, 2193-2198.

20. Synthesis and Synthesis-Based Structural Elucidation of (-)-Macrosphelides J and K, An, H.; Kim, S.-H.; Kim, H.; Kim, K.; Sim, J.; Jang, J.; Paek, S.-M.; Suh, Y.-G.; Yun, H.* Heterocycles 2015, 91, 970-988.

19. Redirection of Genetically Engineered CAR-T Cells Using Bifunctional Small Molecules, Kim, M. S.†; Ma, J. S. Y.†; Yun, H.†; Cao, Y.; Kim, J. Y.; Chi, V.; Wang, D.; Woods, A.; Sherwood, L.; Caballero, D.; Gonzalez, J.; Schultz, P. G.; Young, T. S.; Kim, C. H. J. Am. Chem. Soc. 2015, 137, 2832?2835. († equally contributed)

18. Design and synthesis of a macrosphelide A-biotin chimera, Yun, H.; Sim, J.; An, H.; Lee, J.; Lee, H. S.; Shin, Y. K.; Paek, S.-M.; Suh, Y.-G. Org. Biomol. Chem. 2014, 12, 7127-7135.

17. Glucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C17-side chain, Kim, K.; Maharjan, S.; Lim, C.; Kim, N.-J.; Agrawal, V.; Han, Y. T.; Lee, S.; An, H.; Yun, H.; Choi, H.-J.; Kwon, Y.-G.; Suh, Y.-G. Eur. J. Med. Chem. 2014, 75, 184-194.

16. Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock, Chun, S. K.; Jang, J.; Chung, S.; Yun, H.; Kim, N.-J.; Jung, J.-W.; Son, G. H.; Suh, Y.-G.; Kim, K. ACS Chemical Biology 2014, 9, 703-710.

15. Bispecific small molecule-antibody conjugate targeting prostate cancer, Kim, C. H.; Axup, J. Y.; Lawson, B. R.; Yun, H.; Tardif, V.; Choi, S. H.; Zhou, Q.; Dubrovska, A.; Biroc, S. L.; Marsden, R.; Pinstaff, J.; Smider, V. V.; Schultz, P. G. Proc. Natl. Acad. Sci. U S A. 2013, 110, 17796-17801.

14. Synthesis of 5,6-dihydrophenanthridines via N,O-acetal TMS ethers, Lee, W.-I.; Jung, J.-W.; Jang, J.; Yun, H.; Suh, Y.-G. Tetrahedron Lett. 2013, 54, 5167-5171.

13. Stereoselective Synthesis of 7-epi-Incarvilline, Seo, H.†; Yun, H.†; Lee, S.; Jang, J.; Han, Y. T.; Kim, D.-D.; Lee, J.; Suh, Y.-G. Org. Lett. 2013, 15, 531-533. († equally contributed)

12. Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and Their TRPV1 Binding Modes: Constraint-induced Enhancement of In Vitro and In Vivo Activities, Kim, N.-J.; Li, F.-N.; Lee, J. H.; Park, S.-g.; Kim, K.; Lim, C.; Han, Y. T.; Yun, H.; Jung, J.-W.; Park, H.-g.; Kim, H.-D.; Woo, B. Y.; Shin, S. S.; Kim, S.-Y.; Choi, J. K.; Jeong, Y.-S.; Park, Y.; Park, Y.-H.; Kim, D.-D.; Choi, S.; Suh, Y.-G. Chem. Asian J. 2013, 8, 400-409.

11. Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis, Chang, D.-J.; An, H.; Kim, K.-s.; Kim, H. H.; Jung, J.; Lee, J. M.; Kim, N.-J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Lee, J. S.; Cha, J.-H.; Park, J.-H.; Park, J. W.; Lee, S.-C.; Kim, S. G.; Kim, J. H.; Lee, H.-Y.; Kim, K.-W.; Suh, Y.-G. J. Med. Chem. 2012, 55, 10863-10884.

10. Ligand-Based Design, Synthesis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors, Han, Y. T.; Choi, G.-I.; Son, D.; Kim, N.-J.; Yun, H.; Lee, S.; Chang, D. J.; Hong, H.-S.; Kim, H.; Ha, H.-J.; Kim, Y.-H.; Park, H.-J.; Lee, J.; Suh, Y.-G. J. Med. Chem. 2012, 55, 9120-9135.

9. Achiral auxiliary-assisted chiral transfer via microwave-accelerated aza-Claisen rearrangement: a short synthesis of (+)-1-hydroxyquinolizidinone, Sim, J.; Yun, H.; Jung, J.-W.; Lee, S.; Kim, N.-J.; Suh, Y.-G. Tetrahedron Lett. 2012, 53, 4813-4815.

8. Asymmetric Syntheses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine, Yun, H.; Kim, J.; Sim, J.; Lee, S.; Han, Y. T.; Chang, D.-J.; Kim, D.-D.; Suh, Y.-G. J. Org. Chem. 2012, 77, 5389-5393.

7. A stereo-controlled access to functionalized macrolactams via an aza-Claisen rearrangement, Suh, Y.-G.; Lee, Y.-S.; Kim, S.-H.; Jung, J.-K.; Yun, H.; Jang, J.; Kim, N.-J.; Jung, J.-W. Org. Biomol. Chem. 2012, 10, 561-568.

6. Expedient Synthesis of Chiral Homoallylamines via N,O-Acetal TMS Ethers and Its Application, Suh, Y.-G.; Jang, J.; Yun, H.; Han, S. M.; Shin, D.; Jung, J.-K.; Jung, J.-W. Org. Lett. 2011, 13, 5920-5923.

5. A Versatile Synthetic Approach to Grandisol Monoterpene Pheromone, Han, Y. T.; Kim, N.-J.; Jung, J.-W.; Yun, H.; Lee, S.; Suh, Y.-G. Arch. Pharm. Res. 2011, 34, 1437-1442.

4. Enantioselective Total Synthesis of a Natural Iridoid, Lee, S.; Paek, S.-M.; Yun, H.; Kim, N.-J.; Suh, Y.-G. Org. Lett. 2011, 13, 3344-3347.

3. Concise and Enantioselective Total Synthesis of 15-Deoxy-Δ12,14-Prostaglandin J2, Kim, N.-J.; Moon, H.; Park, T.; Yun, H.; Jung, J.-W.; Chang, D.-J.; Kim, D.-D.; Suh, Y.-G. J. Org. Chem. 2010, 75, 7458-7460.

2. First total syntheses of (-)-macrosphelides J and K and elucidation of their absolute configuration, Yun, H.; Paek, S.-M.; Jung, J.-W.; Kim, N.-J.; Kim, S.-H.; Suh, Y.-G. Chem. Commun. 2009, 2463-2465.

1. Concise Syntheses of (+)-Macrosphelides A and B: Studies on the Macro-Ring Closure Strategy, Paek, S.-M.; Yun, H.; Kim, N.-J.; Jung, J.-W.; Chang, D.-J.; Lee, S.; Yoo, J.; Park, H.-J.; Suh, Y.-G. J. Org. Chem. 2009, 74, 554-561.