학력 Education   

1992. 03 - 1996. 02            부산대학교 약학대학 학사      

1996. 03 - 1998. 02            부산대학교 약학대학 석사     

1998. 03 - 2001. 02            부산대학교 약학대학 박사     

 경력 Experience

2001. 04 - 2002. 08           Arizona Cancer Center, University of Arizona, Post-doctoral fellow     

2002. 09 - 2006. 06           Harvard Medical School, Post-doctoral fellow     

2006. 06 - 2007. 07           Schepens Eye Research Institute, Senior Scientific Associate     

2006. 10 - 2007. 07           Harvard Medical School,   전임강사      

2007. 08 - 2012. 02           University of California at Los Angeles,   조교수      

2012. 03 - 2016. 02           부산대학교 약학대학,  조교수  
2016. 03 - 2021. 02           부산대학교 약학대학,  부교수

2021. 03 - 현재                    부산대학교 약학대학,  교수

 연구업적 Achievements    

Original articles      

1.  Im E , Jung J, Pothoulakis C, Rhee SH. Disruption of Pten Speeds Onset and Increases Severity of Spontaneous Colitis in Il10-/- Mice. Gastroenterology 2014 Sep;147(3):667-679.e10.

2. Kim DH, Hossain MA, Kang YJ, Jang JY, Lee YJ, Im E , Yoon JH, Kim HS, Chung HY, Kim ND. Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice. Int J Oncol 2013 Nov;43(5):1652-8.

3. Kim DH, Sung B, Kang YJ, Jang JY, Hwang SY, Lee Y, Kim M, Im E , Yoon JH, Kim CM, Chung HY, Kim ND. Anti-inflammatory effects of betaine on AOM/DSS induced colon tumorigenesis in ICR male mice. Int J Oncol   2014 2014 Sep;45(3):1250-6.

4. Choi YJ, Jung J, Chung HK, Im E , Rhee SH. PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment. FASEB J 2013 Jan;27(1):243-54.

5.  Im E , Jung J, Rhee SH. Toll-like receptor 5 engagement induces IL-17C expression in intestinal epithelial cells. J Interferon Cytokine Res 2012 Dec;32(12):583-91.

6.  Im E , Riegler FM, Pothoulakis C, Rhee SH. Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune-modulator impaired mice. Am J Physiol Gastrointest Liver Physiol(Selected for the Editor’s pick) 2012 Aug:303(4):G490-7.

7. Aranda J, Motiejunaite R, Im E , Kazlauskas A. Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes 2012 May;61(5):1225-33.

8. Gourcerol G, Wu SV, Yuan PQ, Pham H, Miampamba M, Larauche M, Sanders P, Amano T, Polak A, Im E , Pothoulakis C, Rivier J, Tache Y, Million M. Activation of Corticotropin-Releasing Factor Receptor 2 Mediates the Colonic Motor Coping Response to Acute Stress in Rodents. Gastroenterology 2011 May;140(5):1586-1596.e6.

9. Choi YJ*, Im E* , Chung HK, Pothoulakis C, Rhee SH. TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem 2010 Nov 26;285(48):37570-37578 * The authors are equally contributed to this work.

10. Ma EL, Choi YJ, Choi J, Pothoulakis C, Rhee SH, Im E . The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. Int J Cancer 2010 Aug 15;127(4):780-790.

11. Choi YJ*, Im E* ,  Pothoulakis C, Rhee SH. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem 2010 Jul 9; 285(28):21382-21390. * The authors are equally contributed to this work.

12.  Im E , Rhee SH, Park YS, Fiocchi C, Tache Y, Pothoulakis C. Corticotropin-Releasing Hormone Family of Peptides Regulates Intestinal Angiogenesis. Gastroenterology 2010 Jun;138(7):2457-2467, 2467.e1-5.

13.  Im E , Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A. Phospholipase C activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol 2010 May; 30(10):2401-2410.

14.  Im E , Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH. The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. Am J Physiol Gastrointest Liver Physiol (Selected for press release) 2009 Nov; 295(5):G999-G1008.

15.  Im E , Choi YJ, Pothoulakis C, Rhee SH. Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. J Nutr (Selected for the cover image) 2009 Oct; 139(10):1848-1854.

16. Rhee SH, Im E , Pothoulakis C. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology 2008 Aug; 135(2):518-528.

17.  Im E , Kazlauskas A. Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J Biol Chem 2007 Oct; 282(40):29122-29129.

18.  Im E , Kazlauskas A. Regulating angiogenesis at the level of PtdIns-4,5-P2. EMBO J 2006 May; 25(10):2075-2082.

19.  Im E , Venkatakrishnan A, Kazlauskas A. Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell 2005 Aug; 16(8):3488-3500.

20. Rhee SH, Im E , Riegler M, Kokkotou E, O’Brien M, Pothoulakis C. Pathophysiological role of Toll- like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (Track 2) 2005 Sep; 102(38):13610-13615.

Reviews
1.  Im E . Corticotropin-releasing hormone and its biological diversity toward angiogenesis. Intestinal Research 2014 Apr; 12(2):96-102.

2.  Im E , Pothoulakis C. Recent advances in Saccharomyces boulardii research. Gastroenterol Clin Biol 2010 Sep; 34S1:S62-S70.

3.  Im E , Kazlauskas A. PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis. Expert Opin Thera targets 2007 Apr; 11(4):443-451.

4.  Im E , Kazlauskas A. The role of cathepsins in ocular physiology and pathology. Exp Eye Res 2007 Mar; 84(3):383-388.

5. Im E , Kazlauskas A. New insights regarding vessel regression. Cell cycle 2006 Sep; 5(18);2057-2059.