학력 Education 

2015. 02   성균관대학교 약학과 약학사

2020. 02   성균관대학교 약학과 약학박사

 경력 Experience  

2020. 08   성균관대학교 약학과 박사 후 연구원

2023. 02   미국 프린스턴대학교 화학과 박사 후 연구원

2023. 08   인제대학교 약학과 조교수

2023-       현재 부산대학교 약학대학 조교수

 연구업적 Achievements

65. Hur, Ji Yun; Jeong, Eunju; Kim, Young Chan; Lee, Seoung Rak. Strategies for natural product discovery by unlocking cryptic biosynthetic gene clusters in fungi. Separations, 2023, 10, 333.

64. Nguyen, Quynh Nhu; Lee, Seoung Rak; Kim, Baolo; Hong, Joo-Hyun; Jang, Yoon Seo; Lee, Da Eun; Pang, Changhyun; Kim, Ki Hyun; Kang, Ki Sung. Estrogenic Activity of 4-Hydroxy-Benzoic Acid from Acer teg-mentosum via Estrogen Receptor α-Dependent Signaling Pathways. Plants, 2022, 11, 3387.

63. Han, Esther; Lee, Seoung Rak; Hoshino, Shotaro; Seyedsayamdost, R. Mohammad. Targeted discovery of cryptic metabolites with antiproliferative activity. ACS Chem. Biol. 2022, 17, 3121-3130.

62. Lee, Dahae; Yu, Jae Sik; Ha, Ji Won; Lee, Seoung Rak; Lee, Bum Soo; Kim, Jin-Chul; Kim, Jung Kyu; Kang, Ki Sung; Kim, Ki Hyun. Antitumor potential of withanolide glycosides from ashwagandha (Withania somnifera) on apoptosis of human hepatocellular carcinoma cells and tube formation in human umbilical vein endothelial cells. Antioxidants. 2022, 11, 1761.

61. Li, Yuchen; Lee, Seoung Rak; Han, Esther; Seyedsayamdost, R. Mohammad. Momomycin, an antiproliferative cryptic metabolite from the oxytetracycline producer Streptomyces rimosus Angew. Chem. Int. Ed. 2022, 61, e202208573.

60. Lee, Seoung Rak; Seyedsayamdost, R. Mohammad. Induction of diverse cryptic fungal metabolites by steroids and channel blockers. Angew. Chem. Int. Ed. 2022. 61, e202204519.

59. Lee, Seoung Rak; Schalk, Felix; Schwitalla, Jan W.; Guo, Huijuan; Yu, Jae Sik; Song, Moon-yong; Jung, Won Hee; de Beer, Z. Wilhem; Beemelmanns, Christine; Kim, Ki Hyun. GNPS-guided discovery of madurastatins A1, A2, E1, F, and G1, siderophores from the termite-associated Actinomadura sp. RB99. Chem. Eur. J. 2022, 28, e202200612.

58. Lee Seoung Rak, Lee Bum Soo, Yu Jae Sik, Kang Heesun, Yoo Min Jeong, Kim Sil, Kim Jung Kyu, Kim Jin-Chul, Kim Ki Hyun. Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera). J. Ginseng Res. 2022, 46, 357-366.

57. Park, Jong-Duk; Li, Yuchen; Moon, Kyuho; Han, J. Esther; Lee, Seoung Rak; Seyedsayamdost, R. Mohammad. Structural Elucidation of Cryptic Algaecides in Marine Algal-Bacterial Symbioses by NMR Spectroscopy and MicroED. Angew. Chem. Int. Ed. 2022. 61, e202114022.

56. Lee, Seulah; Yu, Jae Sik; Lee, Seoung Rak; Kim, Ki Hyun. Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis. Nat. Prod. Rep. 2022, 39, 512-559

55. Lee, Dahae; Lee Seoung Rak; Park, Bang Ju; Song, Ji Hoon; Kim, Jung Kyu; Ko, Yuri; Kang, Ki Sung; Kim, Ki Hyun. Identification of Renoprotective Phytosterols from the Fruits of Mulberry (Morus alba) against Cisplatin-induced Cytotoxicity in LLC-PK1 Kidney Cells. Plants, 2021, 10, 2481.

54. Lee, Bum Soo; Yoo, Min Jeong; Kang, Heesun; Lee, Seoung Rak; Kim, Sil; Yu, Jae Sik; Kim, Jin-Chul; Jang, Tae Su; Pang, Changhyun; Kim, Ki Hyun. Withasomniferol D, a New Anti-adipogenic Withanolide from the Roots of Ashwagandha (Withania somnifera). Pharmaceuticals 2021, 14, 1017.

53. Lee, Dahae; Lee, Seoung Rak; Kang Ki Sung; Kim, Ki Hyun. Bioactive Phytochemicals from Mulberry: Potential An-ti-inflammatory Effects in Lipopolysaccharide-stimulated RAW 264.7 Macrophages. Int. J. Mol. Sci. 2021, 22, 8120.

52. Lee, Seoung Rak; Guo, Huijuan; Yu, Jae Sik; Park, Minji; Dahse, Hans-Martin; Jung, Won Hee; Beemelmanns Christine; Kim, Ki Hyun. Revised structural assignment of azalomycins based on genomic and chemical analysis. Org. Chem. Front. 2021, 8, 4791.

51. Yu, Jae Sik; Lim, Sung Ho; Lee, Seoung Rak; Choi, Chang-Ik; Kim, Ki Hyun. Antioxidant and anti-inflammatory effects of white mulberry (Morus alba L.) fruits on lipopolysaccharide-stimulated RAW 264.7 macrophages. Molecules 2021, 26, 920.

50. Schorn, Michelle A.; Verhoeven, Stefan; Ridder, Lars; Huber, Florian;…Lee, Seoung Rak;…van der Hooft, Justin J. J. A community resource for paired genomic and metabolomic data mining. Nat. Chem. Biol. 2021, 17, 363-368.

49. Lee, Seoung Rak; Kang, Heesun; Yoo, Min Jeong; Yi, Sang Ah; Beemelmanns, Christine; Kim, Ki Hyun. Anti-adipogenic Pregnane Steroid from a Hydractinia-associated Fungus, Cladosporium sphaerospermum SW67. Nat. Prod. Sci. 2020, 26, 230-235.

48. Lee, Seoung Rak; Schalk, Felix; Schwitalla, Jan; Benndorf, Ren?; Vollmers, John; Kaster, Anne-Kristin; de Beer, Z. Wilhelm; Park, Minji; Ahn, Mi-Jeong; Jung, Won Hee ; Beemelmanns, Christine; Kim, Ki Hyun. Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99. J. Nat. Prod. 2020, 83, 3102-3110.

47. Lee, Seoung Rak; Choi, Jin Hee; Ryoo, Rhim; Kim, Jin-Chul; Pang, Changhyun; Kim, Seon-Hee; Kim, Ki Hyun. Ergostane-Type Steroids from Korean Wild Mushroom Xerula furfuracea that Control Adipocyte and Osteoblast Differentiation. J. Microbiol. Biotechn. 2020, 30, 1-8.

46. Lee. Dahae.; Lee, Seoung. Rak.; Kang, Ki. Sung.; Kim, Ki. Hyun. Benzyl salicylate from the stems and stem barks of Cornus walteri as a nephroprotective agent against cisplatin-induced apoptotic cell death in LLC-PK1 cells. RSC Adv. 2020, 10, 5777-5784.

45. Lee, Seoung Rak; Lee, Dahae; Lee, Bum Soo; Ryoo, Rhim; Pang, Changhyun; Kang, Ki Sung; Kim, Ki Hyun. Phallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus J. Antibiot. 2020, 73, 729-732.

44. Lee, Seul; Woo, Dong-Cheol; Kang, Jeeheon; Ra, Moonjin; Kim, Ki Hyun; Lee, Seoung Rak; Choi, Dong Kyu; Lee, Heejin; Hong, Ki Bum; Min, Sang-Hyun; Lee, Yongjun; Yu, Ji Hoon. The role of the histone methyltransferase EZH2 in liver inflammation and fibrosis in STAM NASH mice. Biology 2020, 9, 93.

43. Lee, Seoung Rak; Kreuzenberg, Nina; Jang, Mina; Oh, Taehoon; Ko, Sung-Kyun; Ahn, Jong Seog; Beemelmanns, Christine; Kim, Ki Hyun. Xyloneside A: a new glycosylated incisterol derivative from Xylaria sp. FB. ChemBioChem. 2020, 21, 1-7.

42. Lee, Seoung Rak; Lee, Dahae; Park, Musun; Lee, Joo Chan; Park, Hyun-Ju; Kang, Ki Sung; Kim, Chang-Eop; Beemelmanns, Christine; Kim, Ki Hyun. Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5-8-5 Tricyclic Diterpene. J. Nat. Prod. 2020, 83, 354-361.

41. Lee, Seoung Rak; Yi, Sang Ah; Nam, Ki Hong; Park, Jae Gyu; Hwang, Jae Sam; Lee, Jaecheol; Kim, Ki Hyun. (±)-Kituramides A and B, pairs of enantiomeric dopamine dimers from the two-spotted cricket Gryllus bimaculatus. Bioorg. Chem. 2020, 95, 103554.

40. Kwon, Seung Hwan; Lee, Seoung Rak; Park, Yong Joo; Ra, Moonjin; Lee, Yongjun; Pang, Changhyun; Kim, Ki Hyun. Suppression of 6-hydroxydopamine-induced oxidative stress by hyperoside via activation of Nrf2/HO-1 signaling in dopaminergic neurons. Int. J. Mol. Sci. 2019, 20, 5832.

39. Lee, Seoung Rak; Yi, Sang Ah; Nam, Kihong; Ryoo, Rhim; Lee, Jaecheol; Kim, Ki Hyun. Pantheric acids A-C from a poisonous mushroom, Amanita pantherina promote lipid accumulation in adipocytes. J. Nat. Prod. 2019, 82, 3489-3493.

38. Lee, Seoung Rak; Lee Dahae; Eom Hee Jeong; Rischer Maja; Ko Yoon-Joo; Kang Ki Sung; Kim Chung Sub; Beemelmanns Christine; Kim Ki Hyun. Hybrid Polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin. Mar. Drugs 2019, 17, 606.

37. Klassen, Jonathan L; Lee, Seoung Rak; Thomas-Poulsen, Michael; Beemelmanns, Christine; Kim, Ki Hyun. Efomycins K and L from a Termite-associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin. Front. Microbiol. 2019, 10, 1739.

36. Lee, Dahae; Lee, Seoung Rak; Kang, Ki Sung; Ko, Yuri; Pang, Changhyun; Yamabe, Noriko; Kim, Ki Hyun. Betulinic acid suppresses ovarian cancer cell proliferation through induction of apoptosis. Biomolecules, 2019, 9, 257.

35. Yoon, Sun-Young; Lee, Seoung Rak; Hwang, Ji Young; Benndorf, Ren?; Beemelmanns, Christine; Chung, Sang Jeon; Kim, Ki Hyun. Fridamycin A, a microbial natural product, stimulates glucose uptake without inducing adipogenesis. Nutrients, 2019, 11, 765.

34. Lee, Tae-Kyoung; Lee, Dahae; Lee, Seoung Rak; Ko, Yoon-Joo; Kang, Ki Sung; Chung, Sang Jeon; Kim, Ki Hyun. Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells. Bioorg. Chem., 2019, 87, 117-122.

33. Jo, Beom-Geun ; Park, No-June; Kim, Su nam; Jegal, Jonghwan ; Choi, Sang Ho ; Lee, Sang Woo ; Yi, Li Wan ; Lee, Seoung Rak ; Kim, Ki Hyun; Yang, Min Hye. Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice. RSC advances, 2019, 9, 2125-2132.

32. Rischera, Maja; Lee, Seoung Rak; Eom, Hee Jeong; Park, Hyun Bong; Vollmers, John; Kaster, Anne-Kristin; Shin, Yern-Hyerk; Oh, Dong-Chan; Kim, Ki Hyun; Beemelmanns, Christine. Spirocyclic cladosporicin A and cladosporiumins I and J from a hydractinia-associated Cladosporium sphaerospermum SW67. Org. Chem. Front., 2019, 6, 1084-1093.

31. Lee, Seoung Rak; K?fner, Michelle; Park, Minji; Jung, Won Hee; Choi, Sang Un; Beemelmanns, Christine; Kim, Ki Hyun. Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana. Org. Chem. Front. 2019, 6, 162-166.

30. Lee, Seoung Rak; Seok, Soonja; Ryoo, Rhim; Choi, Sang Un; Kim, Ki Hyun. Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom Podostroma cornu-damae. J. Nat. Prod. 2019, 82, 122-128.

29. Lee, Tae kyoung; Trinh, Tuy An; Lee, Seoung Rak; Kim, Sil; So, Hae Min; Moon, Eunjung; Hwang, Gwi Seo; Kang, Ki Sung; Kim, Ji Hwan; Yamabe, Noriko; Kim, Ki Hyun. Bioactivity-based analysis and chemical characterization of anti-inflammatory compounds from Curcuma zedoaria rhizomes using LPS-stimulated RAW264.7 cells. Bioorg. Chem. 2019, 82, 26-32.

28. Lee, Seoung Rak; Park, Yong Joo; Han, Yu Bin; Lee, Ju Chan; Lee, Seulah; Park, Hyun Ju; Lee, Hae-Jeung; Kim, Ki Hyun. Isoamericanoic acid B from Acer tegmentosum as a potential phytoestrogen. Nutrients, 2018, 10, 1915.

27. Lee, Seoung Rak; Lee, Dahae; Yu, Jae Sik; Benndorf, Rene; Lee, Sullim; Lee, Dong-Soo; Huh, Jungmoo; Beer, Z. Wilhelm de; Kim, Yong Ho; Beemelmanns, Christine; Kang, Ki Sung; Kim, Ki Hyun. Natalenamides A-C, cyclic tripeptides from the termite-associated Actinomadura sp. RB99. Molecules, 2018, 23, 3003.

26. Lee, Seoung Rak; Park, Hyun Bong; Kim, Ki Hyun. Highly sensitive, simple, and cost- and time-effective method to determine the absolute configuration of a secondary alcohol using competing enantioselective acylation coupled with LC/MS. Anal. Chem. 2018, 90, 13212-13216.

25. Lee, Seoung Rak; Choi, Eunyong; Jeon, Se Hun; Zhi, Xue Yan; Yu, Jae Sik; Kim, Seon-Hee; Lee, Jeongmi; Park, Ki-Moon; Kim, Ki Hyun. Tirucallane triterpenoids from the stems and stem bark of Cornus walteri that control adipocyte and osteoblast differentiations. Molecules, 2018, 23, 2732.

24. Park, Yong Joo; Lee, Seoung Rak; Kim, Dong Min; Yu, Jae Sik; Beemelmanns, Christine; Chung, Kyu Hyuck; Kim, Ki Hyun. The inhibitory effects of cyclodepsipeptides from the entomopathogenic fungus beauveria bassiana on myofibroblast differentiation in A549 alveolar epithelial cells. Molecules, 2018, 23, 2568.

23. Lee, Seoung Rak; Song, Ji Hoon; Song, Jae-Hyoung; Ko, Hyun-Jeong; Baek, Ji Yun; Trinh, Tuy An; Beemelmanns, Christine; Yamabe, Noriko; Kim, Ki Hyun. Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line. Int. J. Mol. Sci. 2018, 19, 2640.

22. Lee, Dahae; Yu, Jae Sik; Lee, Seoung Rak; Hwang, Gwi Seo; Kang, Ki Sung; Park, Jae Gyu; Kim, Hyun Young; Kim, Ki Hyun; Yamabe, Noriko. Beneficial effects of bioactive compounds in mulberry fruits against cisplatin-induced nephrotoxicity. Int. J. Mol. Sci. 2018, 19, 1117.

21. Song, Ji Hoon; Lee, Dahae; Lee, Seoung Rak; Yu, Jae Sik; Jang, Tae Su; Nam, Joo Won; Kim, Ki Hyun; Kang, Ki Sung. Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Mol. Med. Rep. 2018, 17, 5982-5987.

20. Lee, Seoung Rak; Roh, Hyun Soo; Lee, Seul; Park, Hyun Bong; Jang, Tae Su; Ko, Yoon Joo; Baek, Kwan Hyuck; Kim, Ki Hyun. Bioactivity-guided isolation and chemical characterization of antiproliferative constituents from morel mushroom (Morchella esculenta) in human lung adenocarcinoma cells. J. Funct. Foods, 2018, 40, 249-260.

19. Yu, Jae Sik; Lee, Dahae; Lee, Seoung Rak; Lee, Jae Wook; Choi, Chang Ik; Jang, Tae Su; Kang, Ki Sung; Kim, Ki Hyun. Chemical characterization of cytotoxic indole acetic acid derivative from mulberry fruit (Morus alba L.) against human cervical cancer. Bioorg. Chem. 2018, 76, 28?36.

18. Lee, Yongjun; Kwon, Dong-Joo, Kim, Young Han; Ra, Moonjin; Heo, Seong Il; Ahn, Won Gyeong; Park, Jeong-Ran; Lee, Seoung Rak; Kim, Ki Hyun; Kim, Sun Young. HIMH0021 attenuates ethanol-induced liver injury and steatosis in mice. PLoS ONE 2017, 12, e0185134.

17. Shin, Seung Ho; Lee, Seoung Rak; Lee, Eunjung; Kim, Ki Hyun; Byun, Sanguine. Ca?eic Acid Phenethyl Ester from the Twigs of Cinnamomum cassia Inhibits Malignant Cell Transformation by Inducing c?Fos Degradation. J. Nat. Prod. 2017, 80, 2124?2130.

16. Lee, Seoung Rak; Nam, Joo-Won; Kim, Ki Hyun. New Triterpenoids from the Stems of Cornus walteri. Chem. Pharm. Bull. 2017, 65, 683?686.

15. Lee, Seoung Rak; Moo, Eunjung; Kim, Ki Hyun. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil. Phytochem. Lett. 2017, 20, 98-101.

14. Lee, Seoung Rak; Lee, Dahae; Lee, Hae-Jeung; Noh, Hyung Jun; Jung, Kiwon; Kang, Ki Sung; Kim, Ki Hyun. Renoprotective chemical constituents from an edible mushroom, Pleurotus cornucopiae in cisplatin-induced nephrotoxicity. Bioorg. Chem. 2017, 71, 67?73

13. Lee, Seoung Rak; Lee, Seulah; Moon, Eunjung; Park, Hye-Jin; Park, Hyun Bong; Kim, Ki Hyun. Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorg. Chem. 2017, 70, 94-99

12. Byun, Sanguine; Shin, Seung Ho; Park, Jiman; Lim, Semi; Lee, Eunjung; Lee, Chaeyoon; Sung, Dongeun; Farrand, Lee; Lee, Seoung Rak; Kim, Ki Hyun; Dong, Zigang; Lee Sam W.; Lee, Ki Won. Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization. Mol. Nutr. Food Res. 2016, 60, 1068?1078.

11. Lee, Seoung Rak; Park, Jun Yeon, Yu, Jae Sik, Lee, Sung Ok; Ryu, Ja-Young; Choi, Sang-Zin; Kang, Ki Sung; Yamabe, Noriko; Kim, Ki Hyun. Odisolane, a Novel Oxolane Derivative and Antiangiogenic Constituents from the Fruits of Mulberry (Morus alba L.). J. Agric. Food Chem. 2016, 64, 3804?3809

10. Lee, Seoung Rak; Beemelmanns, Christine; Tsuma, Leah M. M.; Clardy, Jon; Cao, Shugeng; Kim, Ki Hyun. A new diketopiperazine, cyclo(D-trans-Hyp-L-Leu) from a Kenyan bacterium Bacillus licheniformis LB 8CT. Nat. Prod. Commun. 2016, 11, 461-463

9. Lee, Seoung Rak; Clardy, Jon; Senger, Donald R.; Cao, Shugeng; Kim, Ki Hyun. Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina. Braz. J. Pharmacog. 2016, 26, 281-284.

8. Suh, Won Se; Lee, Seoung Rak; Kim, Chung Sub; Moon, Eunjung; Kim, Sun Yeou; Choi, Sang Un; Kang, Ki Sung; Lee, Kang Ro; Kim, Ki Hyun. A new monoacylglycerol from the fruiting bodies of Gymnopilus spectabilis. J. Chem. Res. 2016, 40, 156-159

7. Lee, Seoung Rak; Han, Ju-Yeon; Kang, Hee Rae; Lee, Hye Lim; Noh, Hyung-Jun; Cha, Jae?Soon; Kang, Ki Sung; Lee, Chan-Jung; Kim, Ki Hyun. A New Steroidal Saponin from the Tubers of Ophiopogon japonicus and Its Protective Effect Against Cisplatin-Induced Renal Cell Toxicity J. Braz. Chem. Soc. 2016, 27, 706-711.

6. Kang, Hee Rae; Lee, Dahae; Eom, Hee Jeong; Lee, Seoung Rak; Lee, Kang Ro; Kang, Ki Sung; Kim, Ki Hyun. Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity. J. Funct. Foods, 2016, 20, 358?368.

5. Lee, Seoung Rak; Jung, Kiwon; Noh, Hyung Jun; Park, Yong Joo; Lee, Hye Lim; Lee, Kang Ro; Kang, Ki Sung; Kim, Ki Hyun. A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorg. Med. Chem. Lett. 2015, 25, 5712?5715.

4. Lee, Seulah; Jung, Kiwon; Lee, Dahae; Lee, Seoung Rak; Lee, Kang Ro; Kang, Ki Sung; Kim, Ki Hyun. Protective effect and mechanism of action of lupane triterpenes from Cornus walteri in cisplatin-induced nephrotoxicity. Bioorg. Med. Chem. Lett. 2015, 25, 5613?5618.

3. Kim, Ki Hyun; Moon, Eunjung; Lee, Seoung Rak; Park, Kyoung Jin; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro. Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity. J. Braz. Chem. Soc. 2015, 26, 2307-2312.

2. Choi, Chang-Ik; Lee, Seoung Rak; Kim, Ki Hyun. Antioxidant and α-glucosidase inhibitory activities of constituents from Euonymus alatus twigs. Ind. Crop. Prod. 2015, 76, 1055?1060.

1. Kang, Hee Rae; Eom, Hee Jeong; Lee, Seoung Rak; Choi, Sang Un; Kang, Ki Sung; Lee, Kang Ro; Kim, Ki Hyun. Bioassay-guided Isolation of Antiproliferative Triterpenoids from Euonymus alatus Twigs. Nat. Prod. Commun. 2015, 10, 1929?1932.