학력 Education  

경력 Experience    

2015. 08 - 2017. 05     이화여자대학교 (박사후 연구원)
2017. 06 - 2020. 03     이화여자대학교 (연구교수)
2020. 03 - 2021. 08     한국한의학연구원 (연구원)
2021. 09 - 현재             부산대학교 약학대학 (조교수)

연구업적 Achievements 

(*: equal contribution, †: Corresponding author)

1. Choi JY*, Lee H*, Kwon EJ*, Kong HJ, Kwon OS, Cha HJ†, TGF-β promotes YAP dependent AXL induction in mesenchymal lung cancer cells, Molecular Oncology, 15(2):679-696 (2021)

2. Kong HJ, Kwon EJ, Kwon OS, Lee H, Choi JY, Kim YJ, Kim W, Cha HJ†, Crosstalk between YAP and TGF-β regulates SERPINE1 expression in mesenchymal lung cancer cells. International Journal of Oncology, 58(1):111-121 (2021)

3. Kwon OS, Kwon EJ, Kong HJ, Choi JY, Kim YJ, Lee EW, Kim W, Lee H†, Cha HJ†, Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis. Redox Biology, 37:101719 (2020)

4. Kwon OS*, Lee H*, Kong HJ, Park JE, Lee W, Kang S, Kim M, Kim W†, Cha HJ†, Connectivity Map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer. Oncogene, 39(23):4567-4580 (2020)

5. Jeon J*, Noh HJ*, Lee H, Park HH, Park SH, Lee H, Kim SJ, Kang HC, Eyun SI, Yang S†, Kim YS†, TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis. Annals of the Rheumatic Diseases, 79(12):1635-1643 (2020)

6. Park DR, Kim JH, Kim KM, Lee H, Kim M, Hwang D, Lee H, Kim HS, Kim W, Park MC, Shim H, Choi Y, Lee SY†, Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Nature Communications, 11(1):4343 (2020)

7. Kim KT*, Park JC*, Lee H, Jang HK, Jin Y, Kim W, Lee J, Kim H, Bae S, Cha HJ†, Safe Scarless Cassette-free Selection of Genome-edited Human Pluripotent Stem Cells Using Temporary Drug Resistance. Biomaterials, 262:120295 (2020)

8. Jeong M, Seong D, Seo J, Shin JY, Lee SY, Nam YW, Jo JY, Lee H, …, Oberst A, Vandenabeele P, Shin DH, Lee EW†, Song J†, Identification of MYC as an anti-necroptotic protein that stifles RIPK1-RIPK3 complex formation. Proceedings of the National Academy of Sciences, 117(33):19982-19993 (2020)

9. Kwon OS, Lee H, Kim YJ, Cha HJ, Song NY†, Lee MO†, ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis. Cancers, 12(4):909 (2020)

10. Kwon OS, Kim W, Cha HJ, Lee H†, In silico drug repositioning: from large-scale transcriptome data to therapeutics. Archives of Pharmacal Research, 42(10):879-889 (2019)

11. Go YH*, Lim C*, Jeong HC*, Kwon OS, Chung S, Lee H, .., Lee MO†, Cha HJ†, Kim SH†, Structure-activity relationship analysis of YM155 for inducing selective cell death of human pluripotent stem cells. Frontiers in Chemistry, 7:298 (2019)

12. Park S, Kwon Y, Jung H, Jang S, Lee H, Kim W†, CSgator: an integrated web platform for compound set analysis. Journal of Cheminformatics, 11(1):17 (2019)

13. Hong SK*, Lee H*, Kwon OS*, …, Kim W†, Cha HJ†, Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer, Molecular Cancer. 17(1):175 (2018)

14. Lee H, Kang S, Kim W†, Drug Repositioning for cancer therapy based on large-scale drug-induced transcriptional signature. PLoS ONE, 11(3):e0150460, (2016)

15. Yoo HY*, Sung MK*, Lee SH, Kim S, Lee H, …, Lee S†, Ko YH†, A recurrent inactivating mutation in RHOA GTPase in angioimmuno-blastic T cell lymphoma. Nature Genetics, 46(4):371-5 (2014)

16. Kim P, Yoon S, Kim N, Lee S, Ko M, Lee H, Kang H, Kim J, Lee S†, ChimerDB 2.0-a knowledgebase for fusion genes updated. Nucleic Acids Research, 38(Database issue):D81-5 (2010)