학력 Education  

2003. 03 - 2007. 02    서울대학교 약학과 (학사)

2007. 03 - 2009. 02    서울대학교 약학과 (석사)

2012. 08 - 2017. 05    미국 텍사스대학교 UT Southwestern Medical Center (박사)

경력 Experience    

2009. 01 - 2012. 04    유한양행 중앙연구소 (연구원, 선임연구원)
2017. 06 - 2021. 02    미국 국립보건원 NIH / NIAAA (박사후연구원)
2021. 03 - 현재             부산대학교 약학대학 (조교수)

연구업적 Achievements 

1. He Y, Feng D, Hwang S, Mackowiak B, Wang X, Xiang X, Rodrigues RM, Fu Y, Ma J, Ren T, Ait-Ahmed Y, Xu M, Liangpunsakul S, Gao B. Interleukin-20 exacerbates acute hepatitis and bacterial infection by downregulating IκBζ target genes in hepatocytes. J Hepatol (in press, doi:10.1016/j.hep.2021.02.004).

2. He Y, Rodrigues RM, Wang X, Seo W, Ma J, Hwang S, Fu Y, Trojnar E, Matyas C, Zhao S, Ren R, Feng D, Pacher P, Kunos G, Gao B. Neutrophil-to-hepatocyte communication in steatohepatitis via the selective LDLR-dependent extracellular vesicle transfer. J Clin Invest (in press, doi: 10.1172/JCI141513).

3. He Y,* Hwang S,* Ahmed YA, Feng D, Li N, Ribiero M, Lafdil F, Kisseleva T, Szabo G, Gao B. Immunopathobiology and therapeutic targets related to cytokines in liver diseases. Cell Mol Immunol 2021; 18(1):18-37 (*equal contribution).

4. Xiang X, Hwang S, Feng D, Shah VH, Gao B. Interleukin-22 in alcoholic hepatitis and beyond. Hepatol Int 2020;14(5):667-676.

5. Hwang S,* Ren T,* Gao B. Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake. Clin Mol Hepatol 2020;26(4):586-594 (*equal contribution).

6. Hwang S,* Wang X,* Rodrigues RM, Ma J, He Y, Seo W, Park SH, Kim SJ, Feng D, Gao B. Protective and detrimental roles of p38a mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease. Hepatology 2020;72(3):873-891 (*equal contribution).

7. Hwang S, He Y, Xiang X, Seo W, Kim SJ, Ma J, Ren T, Park SH, Zhou Z, Feng D, Kunos G, Gao B. Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets. Hepatology 2020;72(2):412-429 (SELECTED AS COVER ARTICLE).

8. Ma J, Cao H, Rodrigues RM, Xu M, Ren T, He Y, Hwang S, Feng D, Ren R, Yang P, Liangpunsakul S, Sun J, Gao B. Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKa-dependent mechanisms. JCI Insight 2020;5(14):e136496.

9. Hwang S, Feng D, Gao B. Interleukin-22 acts as a mitochondrial protector. Theranostics 2020;10(17):7836-7840.

10. Jun DJ, Schumacher MM, Hwang S, Kinch LN, Grishin NV, DeBose-Boyd RA. Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation. J Lipid Res 2020;61(5):746-757.

11. Xiang X, Feng D, Hwang S, Ren T, Wang X, Trojnar E, Matyas C, Mo R, Shang D, He Y, Seo W, Shah VH, Pacher P, Xie Q, Gao B. Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice. J Hepatol 2020;72(4):736-745.

12. Seo W, Gao Y, He Y, Sun J, Xu H, Feng D, Park SH, Cho YE, Guillot A, Ren T, Wu R, Wang J, Kim SJ, Hwang S, Liangpunsakul S, Yang Y, Niu J, Gao B. ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. J Hepatol 2019;71(5):1000-1011.

13. Hwang S, Gao B. How does your fat affect your liver when you drink? J Clin Invest 2019;129(6):2181-2183.

14. He Y, Hwang S, Cai Y, Kim SJ, Xu M, Yang D, Guillot A, Feng D, Seo W, Hou X, Gao B. MicroRNA-223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes. Hepatology 2019;70(4):1150-1167.

15. Kim SJ, Feng D, Guillot A, Dai S, Liu F, Hwang S, Parker R, Seo W, He Y, Godlewski G, Jeong WI, Lin Y, Qin X, Kunos G, Gao B. Adipocyte death preferentially induces liver injury and inflammation through the activation of chemokine (C-C motif) receptor 2-positive macrophages and lipolysis. Hepatology 2019;69(5):1965-1982.

16. Jo Y, Hamilton JS, Hwang S, Garland K, Smith GA, Su S, Fuentes I, Neelam S, Thompson BM, McDonald JG, DeBose-Boyd RA. Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice. eLife 2019;8:e44396.

17. Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA. Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.J Biol Chem 2017;292(22):9382-9393.

18. Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA. Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol metabolism in the liver. J Biol Chem 2016;291(26):13479-13494.

19. Hwahng SH,* Ki SH,* Bae EJ, Kim HE, Kim SG. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 2009;49(6):1913-1925 (*equal contribution).