학력 Education

1980. 02   부산대학교 약학대학 약학 학사
1982. 02   서울대학교 대학원 약학 석사
1988. 03   일본 국립 도야마 의과약과대학 약학 박사
1995. 02   미국 텍사스대학교 의과대학 박사후 연구원

 경력 Experience

2021. 09 - 현재            부산대학교 석학교수
1989. 03 - 2021. 08    부산대학교 교수
2000. 09 - 2020. 08    노화조직은행 은행장
2004. 03 - 2005. 02    부산대학교 신약개발연구소 소장
2004. 03 - 2006. 02    부산대학교 약학대학 학장
2007. 09 - 2008. 08    미국 플로리다대학교 의과대학 방문교수
2008. 09 - 2012. 05    부산대학교 장수생명과학기술연구원 원장
2009. 09 - 2018. 08    분자염증노화제어연구센터 센터장

 연구업적 Achievements

1. Park, Y.J., Lee, B., Kim, D.H., Kwon, E.B., Go, Y., Ha, S., Lee M.K., Yu, H.S., Chung, H.Y.; PAR2 Deficiency Induces Mitochondrial ROS Generation and Dysfunctions, Leading to the Inhibition of Adipocyte Differentiation. Oxid Med Cell Longev. 6683033 (2021)

2. Jung, H.J., Choi, D.C., Noh, S.G., Choi, H., Choi, I., Ryu, I.Y., Chung, H.Y., Moon, H.Y.: New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities. Antioxidants, 10, 1078 (2021)

3. Arulkumar, R., Jung, H.J., Noh, S.G., Park, D., Chung, H.Y.: Cheonggukjang-Specific Component 1,3-Diphenyl-2-Propanone as a Novel PPARα/γ Dual Agonist: An In Vitro and In Silico Study. Int J Mol Sci. 22, 10884 (2021)

4. Kim, Y.S., Chung, H, S., Noh, S.G., Lee, B., Chuun, H. Y., Choi, J. G., Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor. Int J Mol Sci. 22, 8604 (2021)

5. . Park, J.H., Kim, H., Moon, H.Y., Park, B.W., Park, J.H., Sim, W.S., Kim, J.J., Lim, H.J., Kim, Y.J., Ji, S.T., Jang, W.B., Rethineswaran, V.K., Van, T.H., Giang, L.T.T., Yun, J., Ha, J.S., Ban, K., Chung, H.Y., Baek, S.H., Park, H.J., Kwon, S.M., Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair. Exp Mol Med, 53(9): 1423-1436 (2021)

6. Moon, K.M., Lee, B., Kim, D.H., Chung, H.Y.: FoxO6 inhibits melanogenesis partly by elevating intercellular antioxidant capacity. Redox Biol. 36, 101624 (2020)

7. Lee, A.K., Kim, D.H., Bang, E., Choi, Y.J., Chung, H.Y.: β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling. Aging Dis. 11(4):777-790 (2020)

8. Kim, D.H., Bang, E., Jung, H.J., Noh, S.G., Yu, B.P., Choi, Y.J., Chung, H.Y.: Anti-aging Effects of Calorie Restriction (CR) and CR Mimetics based on the Senoinflammation Concept. Nutrients. 12(2):422 (2020)
 

9. Chung, K.W., Chung, H.Y.: The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention. Nutrients. 11(12):2923 (2019)

 
10. Kim, D.H., Ha, S., Choi, Y. J., Dong, H. H, Yu B. P, Chung, H.Y.: Altered FoxO1 and PPARγ interaction in age-related ER stress-induced hepatic steatosis. Aging 11(12):4125-4144 (2019)
 

11. Jung, H.J., Noh, S.G., Park, Y., Kang, D., Chun, P., Chung, H.Y., Moon, H.R.: In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives. Comput Struct Biotechnol J. 17:1255-1264 (2019)

12. Chung, H.Y., Kim, D.H., Lee, E.K., Chung, K.W., Chung, S.W., Lee, B., Seo, A.Y., Chung, J.H., Jung, Y.S., Im, E., Lee, J.W., Kim, N.D., Choi, Y.J., Im, D.S., Yu, B.P.: Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept. Aging and Dis.10(2):267-382 (2019)

13. Kim, D.H., Park, M.H., Ha, S., Bang, E., Lee, Y.J., Lee, A.K., Lee, J., Yu, B.P., Chung, H.Y.: Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction. Aging (Albany NY) 11(4):1283-1304 (2019)

 
14. Kim, D.H., Park, J.W., Jeong, H.O., Lee, B., Chung, K.W., Lee, Y.J., Jung, H.J., Hyung, M.K., Lee, A.K., Kim, B.M., Lee, J., Yu, B.P., Chung, H.Y.: Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging. Aging and Dis. 10(6):1174-1186 (2019)

 
15. Bang, E., Lee, E.K., Noh, S.G., Jung, H.J., Moon, K.M., Park, M.H., Park, Y.J., Hyun, M.K., Lee, A.K., Kim, S.J., Yang, J., Park, Y., Chun, P., Moon, H.R., Chung, H.Y.: In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT). Exp Dermatol. 28(6):734-737 (2019)

 
16. Chung, K.W., Lee, E.K., Lee, M.K., Oh, G.T., Yu, B.P., Chung, H.Y.: Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. J AM SOC NEPHROL, 29(4):1223-1237 (2018)

17. Bang, E., Noh, S.G., Ha, S., Jung, H.J., Kim, D.H., Lee, A.K., Hyun, M.K., Kang, D., Lee, S., Park, C., Moon, H.R., Chung, H.Y.: Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico. Molecules. 23(12):3307 (2018)

18. Kim, M.J., Park, C.H., Kim, D.H., Park, M.H., Park, K.C., Hyun, M.K., Lee, A.K., Moon, H.R., Chung, H.Y.: Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats. Molecules, 23(8):2057 (2018)
 

19. Kim, M.J., An, H.J., Kim, D.H., Lee, B., Lee, H.J., Ullah, S., Kim, S.J., Jeong, H.O., Moon, K.M., Lee, E.K., Yang, J., Akter, J., Chun, P., Moon, H.R., Chung, H.Y.: Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. Bioorg Med Chem Lett, 28(4):684-688 (2018)

20. Jung, H.J., Lee, A.K., Park, Y.J., Lee, S., Kang, D., Jung, Y.S., Chung, H.Y., Moon, H.R.: (2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells. Molecules. 23(6):1415 (2018)

21. Lee, E.K., Chung, K.W., Kim, Y.R., Ha, S., Kim, S.D., Kim, D.H., Jung, K.J., Lee, B., Im, E., Yu, B.P., Chung, H.Y.: Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney. Aging Cell, 16(5):1026-1034 (2017)

 
22. Chung, K.W., Kim, K.M., Choi, Y.J., An, H.J., Lee, B., Kim, D.H., Lee, E.K., Im, E., Lee, J., Im, D.S., Yu, B.P., Chung, H.Y.: The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis. Autophagy, 13(7), 1113-1129 (2017)
 

23. Kim, D.H., Kim, S.M., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., An, H.J., Kim, K.M,. Yu, B.P., Chung, H.Y.: Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. J Nutr Biochem, 45,104-114 (2017)

24. Kim, Y.R., Lee, E.K., Kim, D.H., Kim, K.M., Lee, B., An, H.J., Park, J.W., Moon, K.M., Park, M.H., Chung, K.W., Park, J.Y., Kim, S.J., Yun, H.Y., Son, S., Chun, P., Moon, H.R., Chung, H.Y.: PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol, 92,87-95 (2017)

 
25. Park, J.W., Ha, Y.M., Kim, D.H., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., Kim, K.M., Park, Y.J., Kim, D.H., Yun, H.Y., Chun, P., Moon, H.R., Chung, H.Y.: 4-(6,7-Dihydro-5H-indeno[5,6-d] thiazol-2-yl)benzene-1,3-diol prevents UV-induced melanogenesis and wrinkle formation in HRM-2 hairless mice. J Dermatol Sci, 84(2),213-216 (2016)

26. Kim, C. H., Lee E. K., Choi Y. J., An H. J., Chung H. O., Park D.E., Ghim B. C., Yu B. P., Back J., Chung H. Y.:Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation. Aging Cell, 15(6), 1074-1081 (2016)

27. Park, M.H., Kim, D.H., Kim, M.J., Lee, E.K., An, H.J., Jeong, J.W., Kim, H.R., Kim, S.J., Yu, B.P., Moon, H.R., Chung, H.Y.: Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci,71(3),300-309 (2016)

 
28. Moon, K.M., Jeong, J.W., Lee, B.G., Kim, D.H., Kim, H.R., Woo, Y.W., Lee, E.K., An, H.J., Kim, M.J., Choi, Y.J., Son, S.J., Chun, P.S., Moon, H.R., Chung, H.Y.: Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signaling. Exp Dermatol, 25(8),652-654 (2016)

 
29. Chung, K.W., Lee, E.K., Kim, D.H., An, H.J., Kim, N.D., Im, D.S., Lee, J.W., Yu, B.P., Chung H.Y.: Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/1L-1 for steatohepatitis. Aging Cell, 14(4), 524-533 (2015)

 
30. Chung, K.W., Choi, Y.J., Park, M.H., Jang, E. J., Kim, D.H., Park, B.H., Yu, B.P., Chung, H.Y.: Molecular Insights into SIRT1 Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation. J Gerontol A Biol Sci Med Sci, 70(8), 959-968 (2015)