학력 Education  

1977. 02     부산대학교 (학사)
1981. 08     부산대학교 (석사)
1986. 03     일본 오사카대학 (박사)

 
 경력 Experience 

1986 - 1988     미국 Johns Hopkins University 박사후 연구원
1988 - 1993     경성대학교 약학대학 부교수
1993 - 2020     부산대학교 약학대학 제약학과 교수

2016 - 현재       부산대학교 석학교수

 
 연구업적 Achievements 

1. Ma YJ, Kim CH, Ryu KH, Kim MS, So YI, Lee KJ, Garred P, Lee BL.(2011) Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells. BMB Rep. 2011 May;44(5):335-40.(2011) ISSN-1976-6696

2. Kurokawa K, Gong JH, Ryu KH, Zheng L, Chae JH, Kim MS, Lee BL. (2011) Biochemical characterization of evasion from peptidoglycan recognition by Staphylococcus aureus D-alanylated wall teichoic acid in insect innate immunity. Dev Comp Immunol. 2011 Aug;35(8):835-9. Epub 2011 Mar 29.

3. Hee-Jung Kang, Jeong-mi Ha; Han Sung Kim; Haneulnari Lee; Kenji Kurokawa; Bok Luel Lee (2011) The role of phagocytosis in IL-8 production by human monocytes in response to lipoproteins on Staphylococcus aureus, BBRC, in press (2011) Mar 18;406(3):449-53. Epub 2011 Feb 17.

4. Miwako Asanuma, Kenji Kurokawa, Rie Ichikawa, Kyoung-Hwa Ryu, Jun-Ho Chae, Naoshi Dohmae, Bok Luel Lee and Hiroshi Nakayama ( co-corresponding authors ) (2011) Structural evidences of α-aminoacylated lipoproteins of Staphylococcus aureus, FEBS Journal 278 , 2011 Mar;278(5):716-728 (2011)

5. Sun Hee Park, Rui Jiang, Shunfu Piao, Bing Zhang, Eun-Hye Kim, Hyun-Mi Kwon, Xiao Ling Jin, Bok Luel Lee , and Nam-Chul Ha (co-corresponding authors) (2011) Structural and functional characterization of a highly specific serpin in the insect innate immunity, J. Biol. Chem. Jan 14;286(2):1567-75. Epub 2010 Nov 3.(2011)

6. Liu H, Wu C, Matsuda Y, Kawabata SI, Lee BL , Soderhall K, Soderhall I. (2010) Peptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)? Dev Comp Immunol. 2010 Aug 21. Dev Comp Immunol. 2011 Jan;35(1):51-61. Epub 2010 Aug 22. (2011)

7. KH Ryu, JW Park, K Kurokawa, M Matsushita, BL Lee (2010) The molecular activation and regulation mechanisms of proteolytic Toll signaling cascade in insect innate immunity, Invertebrate Survival Journal 7: 181-191, (2010) ISSN 1824-307X REVIEW

8. Yang Yu, Ji-Won Park, Hyun-Mi Kwon, Hyun-Ok Hwang, In-Hwan Jang, Akio Masuda, Kenji Kurokawa, Hiroshi Nakayama, Won-Jae Lee, Naoshi Dohmae, Jinghai Zhang, and Bok Luel Lee , (2010) Diversity of innate immune recognition mechanism for bacterial polymeric meso-diaminopimelic acid-type peptidoglycan in insects. J. Biol. Chem., in press.

9. Keun-Hwa Park, Kenji Kurokawa, Lili Zheng, Dong-Jun Jung, Koichiro Tateishi, Jun-O Jin, Nam-Chul Ha, Hee Jung Kang, Misao Matsushita, Jong-Young Kwak, Kazue Takahashi, and Bok Luel Lee , (2010) Human serum mannose-binding lectin senses wall teichoic acid glyco-polymer of Staphylococcus aureus, which is restricted in infancy. J. Biol. Chem., in press.

10. Yukichika Tabuchi, Akiko Shiratsuchi, Kenji Kurokawa, Ji Hee Gong, Kazuhisa Sekimizu, Bok Luel Lee , and Yoshinobu Nakanishi, (2010) Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus., J. Immunol. in press.

11. Cerenius L, Kawabata SI, Lee BL , Nonaka M, Soderhall K., (2010) Proteolytic cascades and their involvement in invertebrate immunity., Trends Biochem Sci. 35,361-365

12. Miki Matsuoa, Kenji Kurokawaa, Bok-Luel Lee , and Kazuhisa Sekimizu, (2009) Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus, Biol. Pharm. Bull. 33, 198-203

13. Rui Jiang, Eun-Hye Kim, Ji-Hee Gong, Hyun-Mi Kwon, Chan-Hee Kim, Kyoung-Hwa Ryu, Ji-Won Park, Kenji Kurokawa, Jinghai Zhang, David Gubb, and Bok-Luel Lee , (2009)Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses., J. Biol. Chem. 284, 35652-35658

14. Kenji Kurokawa, Hikaru Mizumura, Tohru Takaki, Yumiko Ishii, Norikazu Ichihashi, Bok Luel Lee , and Kazuhisa Sekimizu, (2009) Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA, J. Biol. Chem. 284, 34201-34210

15. Shiratsuchi Akiko, Shimizu Kaori, Watanabe Ikuko, Hashimoto Yumi, Kurokawa Kenji, Razanajatovo Iony, Park Keun Hwa, Park Hae Kyung, Lee Bok Luel , Sekimizu Kazuhisa, Nakanishi Yoshinobu, (2009) Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages, Immunobiology 129, 268-277

16. Kenji Kurokawa, Hiroshi Hamamoto, Miki Matsuo1, Satoshi Nishida1,Noriko Yamane, Bok Luel Lee , Kazuhisa Murakami, Hideki Maki, and Kazuhisa Sekimizu, (2009) Evaluation of target-specificity of antibacterial agents using S. aureus ddlA mutants and D-cycloserine in a silkworm infection model, Antimicrobial Agents and Chemotherapy, 53, 4025-4027

17. Nicolas Buchon, Mickael Poidevin, Hyun-Mi Kwon, Aurelien Guillou, Valentin Sottas, Bok-Luel Lee and Bruno Lemaitre, (2009) A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway, PNAS, 106, 12442-12447

18. Kyung-Baeg Roh, Chan-Hee Kim, Hanna Lee, Hyun-Mi Kwon, Ji-Won Park, Ji-Hwan Ryu, Kenji Kurokawa, Nam-Chul Ha, Won-Jae Lee, Bruno Lemaitre, Kenneth Soderhall, and Bok Luel Lee , (2009) Proteolytic cascade for the activation of the insect Toll pathway induced by the fungal cell wall component J. Biol. Chem., 284, 19474-19582

19. Xionghui lin; Young-A Kim, Bok-Luel Lee , Kenneth Soderhall and Irene Soderhall,(2009) Identification and properties of a receptor for the invertebrate cytokine astakine, involved in hematopoiesis, Exp Cell Res. 315:1171-1180

20. Kenji Kurokawa, Hanna Lee, Kyung-Baeg Roh, Miwako Asanuma, Yooung Sook Kim, Hiroshi Nakyama, Akiko Shiratsuchi, Youngnim Choi, Osamu Takeuchi, Hee Jung Kang, Naoshi Dohmae, Yoshinobu Nakanishi, Shizuo Akira, Kazushisa Sekimizu, and Bok Luel Lee , (2009) The triacylated ATP binding cluster transporter substrate-binding lipoprotein of staphylococcus aureus functions as anative ligand for the toll-like receptor 2, J. Biol. Chem. 284, 8406-8411

21. Irene Soderhall, Chenglin Wu, Marian Novotny, Bok Luel Lee , and Kenneth Soderhall, (2009) A novel protein acts as a negative regulator of proPO activation and melanization in the freshwater crayfish Pacifastacus leniusculus., J. Biol. Chem., 284: 6301-6310

22.Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL , Sekimizu K., (2009) Pleiotropic roles of poly-glycerolphosphate synthase of lipoteichoic acid in the growth of Staphylococcus aureus cells. J. Bacteriol. 201, 141-151

23. Yum S, Kim MJ, Xu Y, Jin XL, Yoo HY, Park JW, Gong JH, Choe KM, Lee BL , Ha NC. (2009) Structural basis for the recognition of lysozyme by MliC, a periplasmic lysozyme inhibitor in Gram-negative bacteria., Biochem Biophys Res Commun. 378, 244-248

24. Kan H, Kim CH, Kwon HM, Park JW, Roh KB, Lee H, Park BJ, Zhang R, Zhang J, Soderhall K, Ha NC, Lee BL. (2008) From the Cover; Molecular control of phenoloxidase-induced melanin synthesis in an insect., J. Biol. Chem. 283, 25316-25323

25. Cerenius L, Lee BL , Soderhall, K. (2008) The pro-PO system: pros and cons for its role in invertebrate immunity. Trends in Immunology, 29, 263-271

26. Kim S, Yum S, Jo WS, Lee BL , Jeong MH, Ha NC. (2008) expression and biochemical characterization of the periplasmic domain of bacterial outer membrane porin TdeA. J Microbiol Biotechnol., 18, 845-851

27. Shiratsuchi A, Watanabe I, Ju JS, Lee BL , Nakanishi Y. (2008) Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli., Immunology 124, 575-583

28. Kim CH, Kim SJ, Kan H, Kwon HM, Roh KB, Jiang R, Yang Y, Park JW, Lee HH, Ha NC, Kang HJ, Nonaka M, Soderhall K, Lee BL. (2008) A three-step proteolytic cascade mediates the activation of the peptidoglycan-induced toll pathway in an insect. J. Biol. Chem. 283, 7599-7607

29. Haipeng Liu, ,Pikul Jiravanichpaisal, Lage Cerenius, Bok Luel Lee , Irene Soderhall and Kenneth Soderhall, (2007) Phenoloxidase is an important component of the defense against aeromonas hydrophila infection in a crustacean, pacifastacus leniusculus, J. Biol. Chem. 282, 33593-33598

30. S. Ji., Hyun E Park, B. L. Lee , K-K, Kim and Y. Choi , (2007) Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils., J. Periodont. Res. 42, 410-419

31. Kang HJ, Lee SM, Lee HH, Kim JY, Lee BC, Yum JS, Moon HM, Lee BL , (2007) Mannose-binding lectin without the aid of its associated serine proteases alters lipopolysaccharide-mediated cytokine/chemokine secretion from human endothelial cells. Immunology. 122, 335-342

32. Ji-Won Park, Chan-Hee Kim, Jung-Hyun Kim, Byung-Rok Je, Kyung-Baeg Roh, Su-Jin Kim, Hyeon-Hwa Lee, Ji-Hwan Ryu, Jae-Hong Lim, Byung-Ha Oh, Won-Jae Lee, Nam-Chul Ha and Bok-Luel Lee , (2007) Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects, PNAS , 104, 6602-6607

33. Piao S, Kim S, Kim JH, Park JW, Lee BL , Ha NC., (2007) Crystal structure of the serine protease domain of prophenoloxidase activating factor-I. J. Biol. Chem., 282 10783-10791

34. Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, Shiratsuchi A, Lee BL , Higashida H, Nakanishi Y., (2007) Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. Exp Cell Res. 313, 500-510

35. Lin X, Cerenius L, Lee BL , Soderhall K., (2007) Purification of properoxinectin, a myeloperoxidase homologue and its activation to a cell adhesion molecule Biochim. Biophys. Acta. 1770, 87-93

36. Piao S, Jung JY, Park JW, Lee J, Lee BL , Ha NC., (2006) Preliminary X-ray crystallographic analysis of the catalytic domain of prophenoloxidase activating factor-I.Acta Crystallograph Sect F Struct Biol Cryst Commun. 62(Pt 8):771-3

37. Jin Sung Ju, Mi Hyang Cho, Lore Brade†, Jung Hyun Kim, Hae Yun Cho, Ji Won Park, Nam-Chul Ha, Irene Soderhall, Kenneth Soderhall, Helmut Brade and Bok Luel Lee , (2006) A novel 40 kDa protein containing six repeats of an epidermal growth factor-like domain functions as a pattern recognition protein for lipopolysaccharide., J. Immunol., 177(3):1838-1845

38. Ji W. Park, Byung-Rok Je, Shunfu Piao, Seiichi Inamura, Yukari Fujimoto, Koichi Fukase, Shoichi Kusumoto, Nam-Chul Ha, Kenneth Soderhall, Nam-chul Ha, and Bok Luel Lee , (2006) A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade., J. Biol. Chem,. 281(12)7747-7755.

39. Piao S, Song YL, Kim JH, Park SY, Park JW, Lee BL , Oh BL, Ha NC (2005) Crystal structure ofa clip-domain serine protease and functional roles of the clip domains., EMBO J, 24, 4404-4414

40. Zhao M, Soderhall I, Park JW, Ma YG, Osaki T, Ha NC, Wu CF, Soderhall K, Lee BL., (2005) A novel 43 kDa protein as a negative regulatory component of phenoloxidase-induced melanin synthesis. , J. Biol. Chem. , 280(26);24744-24751

41. Piao S, Kim D, Par JW, Lee BL , Ha NC., (2005) Overexpression and preliminary X-ray crystallographic analysis of prophenoloxidase activating factor II, a clip domain family of serine proteases., Biochim. Biophys. Acta., 1752(1):103-106

42. Iwanaga S, Lee BL., (2005) Recent advances in the innate immunity of invertebrate animals. J. Biochem. Mol. Biol., 38(2):128-150

43. Lee Sy, Lee BL , Soderhall K (2004) Processing of crayfish hemocyanin subunits into phenoloxidase., Biochem. Biophys. Res. Commun., 322(2): 490-496

44. Whitten, M. M., I. F. Tew, B. L. Lee and N. A. Ratcliffe, (2004). A novel role for an insect apolipoprotein (apolipophorin III) in beta-1, 3-glucan pattern recognition and cellular encapsulation reactions. J. Immunol., 172(4): 2177-2185

45. Ma, Y. G., M. H. Cho, M. Zhao, J. W. Park, M. Matsushita, T. Fujita and B. L. Lee (2004). Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement., J. Biol. Chem., 279(24): 25307-20312

46. Lee, M. H., T. Osaki, J. Y. Lee, M. J. Baek, R. Zhang, J. W. Park, S. Kawabata,K. Soderhall and B. L. Lee ,(2004) Peptidoglycan recognition proteins involved in 1,3-beta-D-glucan-dependent prophenoloxidase activation system of insect. J. Biol. Chem., 279(5): 3218-3227

47. Choi, T. Y., S. Y. Park, H. S. Kang, J. H. Cheong, H. D. Kim, B. L. Lee , F. Hirose, M. Yamaguchi and M. A. Yoo (2004). Redox regulation of DNA binding activity of DREF (DNA replication-related element binding factor) in Drosophila., Biochem. J. , 378(Pt 3): 833-888

48. Zhang, R., H. Y. Cho, H. S. Kim, Y. G. Ma, T. Osaki, S. Kawabata, K. Soderhall and B. L. Lee , (2003). Characterization and properties of a 1,3-beta-D-glucan pattern recognition protein of Tenebrio molitor larvae that is specifically degraded by serine protease during prophenoloxidase activation., J. Biol. Chem., 278(43): 42072-4209

49. Lee, S. Y., B. L. Lee and K. Soderhall (2003). Processing of an antibacterial peptide from hemocyanin of the freshwater crayfish Pacifastacus leniusculus. J. Biol. Chem., 278(10): 7927-7933

50. Lee, K. Y., R. Zhang, M. S. Kim, J. W. Park, H. Y. Park, S. Kawabata and B. L. Lee (2002). A zymogen form of masquerade-like serine proteinase homologue is cleaved during pro-phenoloxidase activation by Ca2+ in coleopteran and Tenebrio molitor larvae. Eur. J. Biochem., 269(17): 4375-4383

51. Kim, M. S., M. J. Baek, M. H. Lee, J. W. Park, S. Y. Lee, K. Soderhall and B. L. Lee (2002). A new easter-type serine protease cleaves a masquerade-like protein during prophenoloxidase activation in Holotrichia diomphalia larvae., J. Biol. Chem., 277(42): 39999-40004

52. De Gregorio, E., S. J. Han, W. J. Lee, M. J. Baek, T. Osaki, S. Kawabata, B. L. Lee ,S. Iwanaga, B. Lemaitre and P. T. Brey (2002).An immune-responsive Serpin regulates the melanization cascade in Drosophila. Dev. Cell., 3(4): 581-592

53. Choi, J. Y., M. M. Whitten, M. Y. Cho, K. Y. Lee, M. S. Kim, N. A. Ratcliffe and B. L. Lee (2002).Calreticulin enriched as an early-stage encapsulation protein in wax moth Galleria mellonella larvae., Dev. Comp. Immunol., 26(4): 335-343